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The Sovicell TRANSIL High Sensitivity Binding Kit accurately determines the unbound fraction of drugs that are tightly bound to plasma proteins – even when the unbound fraction is well below 1%. The TRANSIL assay yields high recovery for drugs that exhibit too high unspecific binding in other assay systems, or precipitate because of low solubility. The kit determines the fraction of drug bound to plasma indirectly by measuring the partitioning of drug between the plasma proteins and artificial cell membranes.
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Ubiquitination plays a key role in protein degradation and signal transduction. Characterization of ubiquitination sites is important for understanding the role of this modification in cellular processes and disease. Ubiquitination sites are usually identified by detection of Lys-?-Gly-Gly (K-?-GG)-remnant peptides, which are generated by tryptic digestion of proteomes. The di-glycine remnant left at sites of ubiquitination after trypsin digestion through cleavage of the C-terminal –RGG sequence on ubiquitin (K-ε-GG). This Ubiquitin K-ε-GG remnant motif antibody will recognize the di-glycine remnant independent of flanking amino acid sequence.
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Ubiquitin Specific Peptidase 13 Primary Antibody Unconjugated Public Immunogen Range 750-800/863 Host Species Rabbit Target Species Human Rat Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
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An antiviral agent inhibits SARS-CoV-2 Mpro activity (IC50 0 081 UM) prevents HSV-1 and HSV-2 infection in Vero cells at 0 2 UM inhibits DDAH-1 and HDAC8 (IC50s 9 and 0 011 UM for the human enzymes respectively) inhibits bacterial KDO 8-P synthase (Ki 0 026 UM) reduces endothelial tube formation and LPS-induced NO production in primary human dermal microvascular endothelial cells
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